Medical Resources

Well Pacific Cancer Center (WPCC) Photodynamic Therapy (PDT)/ Sonodynamic Therapy (SDT) Program

Introduction:

Well Pacific Cancer Center (WPCC)'s Photodynamic Therapy (PDT) program is one of the novelist medical technologies in treating brain cancers: Glioma (primary & recurrent) of Cerebrand hemisphere / serebellum Hemisphere. Recently, Sonodynamic Therapy (SDT), an upgrade to PDT, has been developed as a newer and improved cancer treatments which is not only effectively treating brain cancers but also other cancer types. Patients now are participating at Well Pacific Cancer Foundation (WPCF) off-shore clinical and medical trials in China.

Technology Outline:

Photodynamic Therapy PDT, developed in the late 1970s in U.S., is a targeted anticancer treatment - one that kills tumor cells without permanently damaging surrounding tissue. The treatment involves the administration of a nontoxic drug that settles in tumor cells, followed by the application of laser light to the tumor, thereby activating the drug and killing the cancer. At present, this cancer therapy technology is gaining acceptance and is widely used to treat various types of cancer in US, including cancers of the skin, lung, breast, gynecological cancers, esophagus, pleura, neck, mouth and larynx. However, brain tumors are that last areas that most medical scientists believe that cancer patients would greatly benefit from this medical technology due to the complexity of this type of cancer.

Also, thanks to medical research scientists at WPCC who has made this powerful technology available to regular brains cancer patients through WPCC's medical clinical trial. This study was led by Dr. Ji (M.D.) and his research team which was successfully launched in December of 2011 with a great success in treating a great number of complex brain tumor cases in conjunction with a phase II clinical study officially approved by the Ministry of Healthcare in P.R. China.

Sonodynamic Cancer Therapy (SDT) is a novel therapeutic modality that utilizes a non-toxic photosensitive agent with reported ultrasound-activated properties. This non-invasive treatment centers around the development of a specific light and ultrasound activated sensitizer which can demonstrate tumor cell inhabitation. SDT is not only perceived as safe but also has excellent tissue penetrating ability to deep malignant tumors which is a significant improvement of photodynamic therapy.

How SDT Works for Brain Tumors:

A non-toxic drug called Photofrin® or its substitute (porfimer sodium, FDA approved) is injected intravenously. Both normal and malignant cells absorb the drug. However, Photofrin® concentrates in the cancer cells in 24 hours and is reduced in the normal cells that are near many cancers. Non-thermal (without heat) red light, which is typically generated by a laser, is focused on the tumor. This light activates the Photofrin®, causing an almost immediate destruction of the tumor cells. The Side Effects of Photofrin -SDT Photofrin is a photosensitizing agent and is retained in the skin. Because of this, patients are required to avoid direct sunlight for a period of 7-10 days on average after the infusion of the drug.

How SDT Works:

Sonodynamic therapy (SDT), which uses low-intensity ultrasound together with a sonosensitizer, has been developed for cancer therapy in applying such properties of ultrasound. So far, most sonosensitizers that have been developed are sensitive to light as well as ultrasound, implying that the shortcomings of photosensitizers used during photodynamic therapy, such as skin sensitivity, still need to be overcome in SDT. In addition, ultrasound can also penetrate tissue better than light, and generally its bio effects are intensity- and frequency-dependent which is a significant improvement of photodynamic therapy.

Program Leadership:

Dr. Ying Ji, research team leader, earns a M.D. from the Medical School of Beijing University (1981) and has his residence in Tiantian Hospital, Beijing (1993). Followed by a 5-year US fellowship in neurosurgeon (brain surgery) at Penn State Hershey Medical Center.

How to Enroll in the WPCC SDT Program:

The off-shore research center is located in one of the most advanced medical facilities in the suburbs of Beijing and patients need to travel to the site. However, a pre-screen can be arranged through remote video conference and email exchange after patient admission and registration (Patient Registration Form, add download button English/Chinese at the end of the page). Please contact WPCC US admitting office at (206) 313.1135 for more information and registration.

US Medical Insurance Coverage:

Unfortunately, most of US medical insurance plans do not cover the off-shore therapy for now. However, the treatment is free and patients are encouraged to make a donation to the WPCC Research Fund at a VIP level.

International Travel Visa:

Patients and family members who provide on-site support are responsible for their international travel visa and airfares. WPCC will assist in travel arrangement on behalf of a patient at a fee ($150 per person) in case of need. WPCC will responsible for ground transportation including airport pick-up and drop-off (in Beijing Airport). The SDT therapy will last about 3 to 7 days. Patient food, lodge and medication are provided by the program.

Click below for more information on Sonodynamic Therapy:

 

SDT Frequently Asked Questions (English)

SDT Frequently Asked Questions (Chinese)

SDT -Japanese Study (English)

SDT -Japanese Study (Chinese)

SDT -British Study (English)

SDT -British Study (Chinese)

 

Key words: brain tumor, photodynamic therapy, pdt, cancer, glioma, Photofrin, WPCF, WPCC, porfimer sodium, off-shore medication, clinical study, clinical trial.

 

 

 

 

Cancer Preventive Program

WPCF sponsors cancer preventive educational programs through medical professional led seminars, newsletter patient reporting and web postings.  Watch for the next seminar "How New Cancer Drug Development Works for Us" by Dr. Hua Mu, Representative of a leading drug company.  To promote community health, we have asked our doctor to provide Q&A session on a regular basis.  Please send your questions to our email: DoctorQ&A@wellpacific.org

Key Words:

brain tumor, photodynamic therapy, pdt, cancer, glioma, Photofrin, WPCF, WPCC, porfimer sodium, off-shore medication, clinical study, clinical trial.

Cancer Preventive Program

WPCF sponsors cancer preventive educational programs through medical professional led seminars, newsletter patient reporting and web postings. Watch for the next seminar "How New Cancer Drug Development Works for Us" by Dr. Hua Mu, Representative of a leading drug company. To promote community health, we have asked our doctor to provide Q&A session on a regular basis. Please send your questions to our email: DoctorQ&A@wellpacific.org